![]() ![]() Coronary venous increased after pacing at 125 beats per minute in patients with HFpEF but not in controls. The volume loss was about twice as much in the HFpEF group (controls −15%☑4% versus patients with HFpEF −32%☑1%, P=0.009). Pacing also reduced LV end‐diastolic volumes. Pacing at 125 beats per minute lowered the mean LV end‐diastolic pressure in both groups (controls −4.3±4.1 mm Hg versus patients with HFpEF −8.5☖.0 mm Hg, P=0.08). Patients with HFpEF had a history of hypertension, dyspnea on exertion, concentric LV remodeling and a dilated left atrium, whereas controls did not. Seven women and 15 men were studied (aged 59☑0 years, ejection fraction 61%±4%). Coronary sinus blood samples and flow measurements were also obtained. In 22 fully sedated and instrumented patients (12 controls and 10 patients with HFpEF) in sinus rhythm with a preserved ejection fraction (≥50%) we assessed left‐sided filling pressures and volumes in sinus rhythm and with atrial pacing (95 beats per minute and 125 beats per minute) before atrial fibrillation ablation. Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA). ![]() Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). ![]()
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